Lyophilized · 5 mg / vial Semax 5 mg / vial — HPLC-verified peptide vial

Cognitive & Sleep 5 mg / vial

Semax 5mg — Synthetic ACTH(4-10) Nootropic

Q: What is Semax?

Semax is a synthetic heptapeptide analog of a fragment of ACTH (residues 4-10), developed in Russia for therapeutic applications. Studies describe BDNF and NGF expression modulation and effects on cognitive performance, particularly in stroke and ischemia research. CAS 80714-61-0.

Q: How is Semax typically used?

Semax is most commonly used as a nasal spray (intranasal) at 150-600 mcg per nostril, 1-3 times daily. The 5mg vial reconstituted in 2mL of saline yields 2.5mg per mL — 0.1mL delivers 250 mcg. Subcutaneous injection is also possible.

Q: How is Semax tested?

Each Semax lot is HPLC-tested to ≥99% purity, confirmed by ESI mass spectrometry, and LAL endotoxin tested. ISO 17025-accredited third-party labs perform the testing.

Q: How do I store Semax?

Lyophilized Semax is stable at -20°C for 24+ months. After reconstitution, store refrigerated at 2-8°C and use within 30 days.

Heptapeptide · BDNF/NGF modulator · Neuroprotective · Cognitive support

Premium Grade

Synthetic analog of ACTH(4-10) with neuroprotective and BDNF/NGF-modulating properties.

CAS Number: 80714-61-0
Molecular Weight: 813.94 Da
Purity: ≥ 99.0% (HPLC)
Storage: −20 °C, lyophilized

Amino Acid Sequence Met-Glu-His-Phe-Pro-Gly-Pro

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1 vial $21 /vial $21 total Most popular 3 vials $15 /vial $45 total Best value 10 vials $11 /vial $110 total

Free over $59$7.99 to US (48h) · $14.99 worldwide (5 business days)

Discreet PackagingPlain insulated mailer, no compound name on the outside.

Certificate of Analysis

Per-lot analytical report — HPLC, ESI-MS, LAL endotoxin, heavy metals, sterility

Current lotSEM665

Released2026-04-24

HPLC purity99.85%

Endotoxin (LAL)Pass · < 0.5 EU/mg

Read Full COA View All Lab Results

About Semax

Buy Semax 5mg at IGF1 Shop. Semax is a synthetic heptapeptide analog (Met-Glu-His-Phe-Pro-Gly-Pro) of a fragment of adrenocorticotropic hormone (ACTH 4-10), developed in Russia for therapeutic use. Widely studied for its effects on BDNF and NGF expression and on cognitive performance in stroke and ischemia models. Each Semax 5mg vial is HPLC ≥99% pure, identity-confirmed by ESI mass-spec against the theoretical 813.94 Da molecular weight, with a per-lot Certificate of Analysis. CAS 80714-61-0.

Also known as: Semax · ACTH(4-10) analog · Russian nootropic

Semax — Mechanism & Specifications

Semax is a synthetic heptapeptide analog of a fragment of adrenocorticotropic hormone (ACTH 4-10), developed in Russia for therapeutic use. Widely studied for its effects on BDNF and NGF expression and on cognitive performance in stroke and ischemia models.

Quality & release criteria

Every lot of Semax is released only after passing reverse-phase HPLC (≥ 99% area purity at 220 nm against a reference standard), ESI mass spectrometry confirmation of molecular weight, and Limulus Amebocyte Lysate (LAL) endotoxin testing below 0.5 EU/mg. The lot-specific Certificate of Analysis is provided with the order and available on request before purchase.

FAQ

Semax — Frequently asked questions

What is Semax?

Semax is a synthetic heptapeptide analog of a fragment of ACTH (residues 4-10), developed in Russia for therapeutic applications. Studies describe BDNF and NGF expression modulation and effects on cognitive performance, particularly in stroke and ischemia research. CAS 80714-61-0.

How is Semax typically used?

Semax is most commonly used as a nasal spray (intranasal) at 150-600 mcg per nostril, 1-3 times daily. The 5mg vial reconstituted in 2mL of saline yields 2.5mg per mL — 0.1mL delivers 250 mcg. Subcutaneous injection is also possible.

How is Semax tested?

Each Semax lot is HPLC-tested to ≥99% purity, confirmed by ESI mass spectrometry, and LAL endotoxin tested. ISO 17025-accredited third-party labs perform the testing.

How do I store Semax?